Vascular smooth muscle dysfunction in migraine

Individuals with migraine have altered vascular tone, especially vasodilation in response to nitric oxide.

This may account for the increased risk of cardiovascular events in migraine, and may also relate to the basic pathology of migraine.

The publication:

June, 2009

Vascular smooth muscle cell dysfunction in patients with migraine.

Summary of the abstract

BACKGROUND: Migraine is associated with increased risk of cardiovascular disease, but the mechanisms are unclear.

OBJECTIVE: To investigate the activity of endothelial and vascular smooth muscle cells (VSMCs) in patients with migraine.

RESULTS: In patients with migraine, the vasodilating effect of acetylcholine (ACh), an endothelium-dependent vasodilator, was markedly reduced. In response to the highest dose of ACh, forearm blood flow (FBF) rose to 8.6 in patients with migraine and to 22.7 . in controls.

The dose-response curve to nitroprusside, a vasodilator directly acting on VSMCs, was depressed in patients with migraine. The maximal response of FBF to nitroprusside was 12.1 in patients with migraine and 24.1 in controls.

CONCLUSIONS: Patients with migraine are characterized by a distinct vascular smooth muscle cell dysfunction, revealed by impaired response to nitric oxide.


One Response to Vascular smooth muscle dysfunction in migraine
  1. […] what we’re looking for, but perhaps of interest: migraine is associated with a lack of responsiveness by vascular smooth muscle to NO. The researchers who investigated seemed to be looking for a way to explain the higher […]