Tag Archive: Fibro Fog

Fibro fog: What causes fibro fog in fibromyalgia?

Fibro Fog Explained with a Mouse Maze

  Inflammatory cytokines impair memory and learning: Fibro fog. Cytokines are inter-cellular chemical messengers produced mostly by white blood cells. Some are generally pro-inflammatory (inflammatory cytokines turn inflammation ‘on’) while others are generally anti-inflammatory (they turn inflammation ‘off’.) Inflammatory cytokines, which are often elevated during sickness, are believed responsible for many of the common symptoms…

Cytokine therapies for fibromyalgia?

Cytokine therapy for fibromyalgia

It is hard to describe a possible cause for all of the diverse symptoms of fibromyalgia without making reference to cytokines, especially the pro-inflammatory cytokines IL-1, IL-6 and IL-8. Only pro-inflammatory cytokine excess offers a single, reasonable explanation for fatigue, sleep impairment, cognitive impairment (fibro-fog,) autonomic dysfunction (e.g.postural orthostatic tachycardia syndrome – POTS,) depression, anxiety,…

How your immune system talks to your brain and messes with your sleep

Immune System and Sleep

Basically, the immune system becomes activated during times of stress. ‘Stress’ can be an infection, an injury, or emotional/psychological stress. The activated immune system releases cytokines (pro-inflammatory cytokines) that communicate with your brain by stimulating nerves. Then your brain also begins releasing cytokines, with a resulting effect on sleep, mood and certain behaviors.

That makes sense, because if you have an injury, an infection, or you’re under a great deal of psychological stress, it’s probably good for you to sleep more. A general sense of fatigue is also beneficial. Your body wants you to stay home, not go out, not work – just lay low until you feel better.

Ultimately the infection clears, the injury heals, or the stressful time passes. Your body sounds the ‘all-clear’ and you’re good to go again.

Inflammatory cytokine IL-8 elevated 300% in fibromyalgia

Elevated Cytokines Graph Image

Substantial evidence has accumulated that cytokines, especially IL-8, may play an important role in the initiation and progression of fibromyalgia.

Cytokines are small molecules that serve as inter-cellular messengers. There are many different types, each with multiple, diverse and sometimes overlapping functions. Understanding of cytokine function is limited, but cytokines are known to play an important role in regulating the immune system.

Alterations in cytokine levels (cytokine dysregulation) has been linked to sleep disorders, hyperalgesia (excess sensitivity to pain signals), stress, ‘aching’, anxiety and cognitive difficulties (e.g. such as with “fibro fog”.)

On investigation, the level of IL-8 in fibromyalgia patients was 300% of that found in healthy controls. Furthermore, only IL-8 levels were shown to increase over time.

Psychological stress increases pro-inflammatory cytokine production

Fibromyalgia Psychological Stress Image

The novel theory of fibromyalgia advanced on this site includes that an increase in pro-inflammatory cytokines, especially IL-8, may be critical in the onset and progression of fibromyalgia.

If that theory is correct, or to the extent that it is correct, it should explain most of the symptoms, associated conditions and observations common to fibromyalgia.

It has been observed that up to about two-thirds of those with fibromyalgia report its initial onset in connection with a highly stressful event or period in their lives. Can the novel theory advanced on this site account for that observation?

A novel theory of fibromyalgia

Natural fibromyalgia relief using anti-inflammatory herbs

This site presents a novel theory. It is proposed that fibromyalgia results from a form of ‘inflammation’ – specifically a dysfunction in the inflammatory response system leading to cytokine imbalance, including a persistent elevation in pro-inflammatory cytokines, especially IL-8.

Cytokine abnormalities, including elevations in IL-8 and other pro-inflammatory cytokines, are well-documented in fibromyalgia. Of special interest, pain intensity has been shown to correlate with IL-8 elevation. When IL-8 levels decrease – so does pain.

IL-8 is a potent activator of NF-kappaB (a central mediator of inflammation.) Once activated (by IL-8 or any one of many other agents,) NF-kappaB triggers the production of more pro-inflammatory cytokines, including more IL-8. This positive feedback loop (IL-8 acts via NF-kappaB to increase the production of IL-8) could easily become a vicious cycle. It seems that might be what happens in those with fibromyalgia, as suggested by the observation that such individuals have excess IL-8 as well as excess NF-kappaB activation.

Can a person have both EDS and fibromyalgia?

Recently heard about a geneticist who, several years after having first diagnosed a patient with Ehlers-Danlos syndrome, was then asked by that patient about a more recent diagnosis of fibromyalgia.

“Oh, fibromyalgia is just a symptom of EDS,” the geneticist is said to have replied.

So the question is, in the case of a patient with EDS, is it possible to make the distinct diagnosis of fibromyalgia?

Why do so few men have fibromyalgia?

Men with Fibromyalgia

The answer is simple. A lot of men actually do have fibromyalgia – but technically, officially, many don’t. At least not according to the most widely recognized diagnostic criteria, which defines fibromyalgia in such a way that few men qualify (official diagnosis) but a lot of men almost qualify (they have the same condition, but…

Fibromyalgia and chronic fatigue syndrome: “Much to my amazement, Banjo actually worked…”

I am now 55 years old and was diagnosed with Fibromyalgia when I was 50. I have had Chronic Fatigue Syndrome since I was 45 and for the last three years have dealt with chronic pressure headaches of which took a year to find a medication that would help (not alleviate) the pain and pressure.

I now have only mild pain, whereas I used to have daily severe pain. I also have a lot more energy and a lot less fatigue. Finally, I’ve noticed a big improvement in my sleep since starting Banjo.

Fibromyalgia: “I was skeptical, but what did I have to lose?”

I’ve had fibromyalgia for the past three years. During that time I’ve tried damn near every drug on the U.S. market with no success.

I was quite skeptical on whether or not this, Banjo, would work, but what did I have to lose, really? I started taking Banjo twice a day about seven weeks ago, and I’ve tried keeping a diary to note changes. I was in the middle of a bad back flare when I started taking Banjo, but almost right away within the first few days felt my pain lessen to where it wasn’t much…

Fibromyalgia and arthritis fatigue, ‘fog’, and pain relieved

Dear Dr. Steve; I have now been taking Banjo for about five weeks. As for what Banjo has done for me, the first thing I noticed immediately was it eliminated my headaches.

I also noticed a big increase in energy almost right away. It was like the fatigue just vanished over a period of about 2 or 3 days. And I didn’t have the pain issues I normally would get whenever I would do any project around the house. I found myself…

Fibromyalgia – why the frequent onset at times of stress?

Fibromyalgia Stress

It appears that somewhere between two-thirds and three-fourths of those with fibromyalgia first developed the condition during or immediately following a period of great stress. Sometimes that’s a physical stress (such as an auto accident or even what seems at the time like a relatively mild injury) – but most often the stress is psychological…

Fibromyalgia as a neuro-immunoendocrine disorder

Fibromyalgia is associated with increased levels of corticotropin-releasing hormone – corticotropin-releasing hormone has been shown to activate NF-kB.

Fibromyalgia is associated with increased levels of substance P, which is also known to activate NF-kB.

Fibromyalgia is associated with inflammation, as evidenced both by the frequent occurrence of other inflammatory conditions in those with fibromyalgia, and by the observation that pro-inflammatory cytokines are found at higher levels in the blood and cerebro-spinal fluid (CSF) of fibromyalgia patients.

The author of the study briefly summarized below suggests the use of anti-inflammatory supplements in the treatment of fibromyalgia and notes that these may be safely combined with other treatments.

Fibromyalgia symptoms – severity related to cytokine levels

Some pro-inflammatory cytokines elevated in fibromyalgia; correlation with pain intensity This is an important publication because it clearly demonstrates that fibromyalgia is a disease of inflammation and that symptomatic relief can be achieved through the reduction of inflammation. Higher than normal levels of pro-inflammatory cytokines in the blood indicate ongoing inflammation. When inflammation is relieved,…