The risk of cancer is reduced as excess NF-kB activation is reduced.
This is an essential publication because it so effectively and efficiently summarizes both the mechanism underlying well-known cancer risks and the means by which we can protect ourselves from those risks.
* Things which put us at risk are those which activate NF-kB – because cancer is a disease of inflammation.
* So the things that protect us are NF-kB inhibitors – fruits and vegetables.
Noteworthy is that the publication originates with M.D. Anderson cancer Center, one of the most well-known and well-respected cancer research and treatment facilities in the world.
I would only add that, according to the theory advocated on this site, an initial deficit in NF-kB inhibitors (as is prevalent in those eating a ‘Western’ diet) is sufficient in and of itself to increase the risk of cancer – because it means that NF-kB is chronically over-activated. Additional exposure to carcinogens increases that risk.
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The anti-cancer drug sorafenib (Nexavar) inhibits NF-kB and may be useful in the treatment of Alzheimer’s.
Sorafenib (Nexavar) was found to inhibit NF-kB in the brains of mice. Inhibition of NF-kB was found to correlate with a reduction in COX-2 and iNOS in those same mouse brains. Memory was found to improve, without any change in the amyloid plaques associated with Alzheimer’s. A reduction in neuro-inflammation is therefore suggested as the reason for the reduction in Alzheimer’s symptoms.
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Most cancer treatments increase NF-kB activation, which might limit or reduce their efficacy.
The study briefly summarized below was undertaken to study the potential benefit of combining curcumin with paclitaxel in the treatment of breast cancer.
Paclitaxel, like most chemotherapeutic agents, increases the activation of NF-kB.Curcumin was found to reduce that NF-kB activation. In a mouse model of breast cancer, curcumin plus paclitaxel was found to be more effective than either agent used alone.
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Over-activation of NF-kB is now recognized as a major contributor to inflammatory bowel disease and cancer. NF-kB activation results in inflammation, obviously of significance in inflammatory bowel disease, but increasingly recognized as central to carcinogenesis.
The relative cancer risk increases with the duration and severity of inflammatory bowel disease.
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Osteoclasts (OCs) are involved in several pathologies associated with bone loss, including rheumatoid arthritis, osteoporosis, bone metastasis of myeloma, osteosarcoma, and breast cancer.
In this review we determined the effects of natural compounds, including extracts from medicinal plants, on differentiation and survival of human primary osteoclasts.
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This study is the first study to investigate the anticancer effect of 6-shogaol in human non-small cell lung cancer. The results suggest that ginger may have some effect in preventing non-small cell cancer of the lung.
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Ginger is known to have potent anti-inflammation and anti-cancer properties. In researching these qualities, many previous efforts have focused on the compounds identified as “gingerols.” This research suggests that more benefits might be obtained by using a full-spectrum extract.
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Even the federal government (USDA) recommends increasing your intake of fruits and vegetables, in part because a higher dietary intake, especially of dark green, deep yellow and other colorful fruits, will reduce your risk of cancer.
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