Synergy of multiple NF-kappaB inhibitors

Turmeric (curcumin) and resveratrol found to act synergistically in the treatment of arthritis.

This is an important publication because it demonstrates that by combining different natural inhibitors of NF-kB, a greater anti-inflammatory effect may be achieved than is possible with either agent alone. The study further suggests that this might be especially true when the different agents act to inhibit NF-kB through different mechanisms.

By implication, the observed synergy will not be limited to the specific combination studied (curcumin + resveratrol.)

Banjo combines a number of different natural NF-kB inhibitors, each of which may act through a slightly different mechanism in the inhibition of NF-kB. While many of the individual agents might provide some benefit, Banjo is expected to provide a substantially greater benefit than any single agent. That possibility is confirmed by the study briefly summarized below.

The publication:

November, 2009

Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosis.

Summary of the abstract

Currently available treatments for osteoarthritis are restricted to NSAIDs like aspirin, which exhibit numerous side effects and are only temporarily effective. Novel, safe and more efficacious anti-inflammatory agents are needed for osteoarthritis.

Naturally occurring compounds, such as curcumin and resveratrol, are potent agents for modulating inflammation. Both compounds work by inhibiting NF-kappaB.

In chondrocytes (cartilage cells) resveratrol modulates the NF-kappaB pathway by inhibiting the proteasome, while curcumin modulates the activation of NF-kB by inhibiting upstream kinases. However, the combined effects of these compounds in chondrocytes has not been studied.

in this study, treatment with curcumin or resveratrol was found to inhibit NF-kappaB.  However, since each works through a distinct mechanism, by combining these two agents in the treatment of osteoarthritis, a greater effect is obtained.

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