Selenium – a natural inhibitor of NF-kB – protects from cardiovascular disease in diabetics.
Diabetic patients were found to have a level of NF-kB activation 80% higher than non-diabetic patients.
Treatment with selenium reduced levels of activated NF-kB to normal, thereby lowering the risk of cardiovascular complications among diabetics.
The publication:
Eur J Clin Invest. 2004 Jul;34(7):475-81.
Selenium supplementation decreases nuclear factor-kappa B activity in peripheral blood mononuclear cells from type 2 diabetic patients.
Faure P, Ramon O, Favier A, Halimi S.
Laboratoire d’Etude de la Physiopathologie de l’Hypoxie, La Tronche, France.
Summary of the abstract
OBJECTIVE: The role of selenium in preventing cardiovascular diseases has been largely described. Oxidative stress and the subsequent activation of nuclear factor-kappa B (NF-kB) have been linked to the development of vascular complications.
This study investigated the effects of selenium supplementation in type 2 diabetic patients on several oxidative stress parameters and NF-kappaB activity.
RESULTS: NF-kB activity was increased by 80% in diabetic patients. Selenium treatment resulted in a significant reduction in NF-kB activity, reaching the same level as the nondiabetic control group.
CONCLUSION: In type 2 diabetic patients, activation of NF-kB can be reduced by selenium supplementation, confirming its importance in the prevention of cardiovascular diseases.
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