Seahorse hydrolysate inhibits collagen breakdown in arthritis by inhibiting activation of NF-kB

You don’t really need to grind up a seahorse to get relief from arthritis pain. Though it might be one way, it’s probably not the best way and definitely not the easiest way. NF-kB inhibitors are all around us.

The publication:

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Peptides. 2009 Nov 4

SHP-1, a novel peptide isolated from seahorse inhibits collagen release through the suppression of collagenases 1, 3, nitric oxide products regulated by NF-kappaB/p38 kinase

Summary of the abstract

Considerable efforts have been taken to identify natural peptides as potential bioactive substances. In this study, novel peptide (SHP-1) derived from seahorse (Hippocampus, Syngnathidae) hydrolysate was explored for its inhibitory effects on collagen release in arthritis; with the investigation of its underlying mechanism of action.

The efficacy of SHP-1 was determined on cartilage protective effects such as inhibition of collagen and GAG release. SHP-1 was able to suppress not only the expression of collagenases 1 and 3, but also the production of NO via down regulation of iNOS.

Inhibition of collagen release by SHP-1 is associated with restraining the phosphorylation of NF-kB (e.g. preventing the activation of NF-kB) and p38 kinase cascade. Therefore, it could be suggested that SHP-1 has a potential to be used in arthritis treatment.

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Comments:

Inhibition of NF-kB by seahorse derived peptide inhibits collagenase production and iNOS

I have to wonder who first thought of looking for a peptide in a seahorse. In any case…

NF-kB inhibitors are all around us. No need to harvest them from the seahorse. While it’s true that some NF-kB inhibitors are very substantially better (stronger) than others, the qualitative (not quantitative) effect of inhibiting NF-kB will be essentially the same.

Yes, NF-kB inhibitors are potentially good treatments for arthritis.