Psoriasis dispute resolved

Keratinocytes or immunocytes? Maybe both, with NF-kB the link

It seems there has been a dispute among psoriasis experts. Which is more important – the keratinocyte or the immunocyte.

It further seems that neither NF-kB activation in the keratinocyte alone, nor in the immunnocyte alone, resulted in psoriasis. However, when NF-kB is over activated in both – psoriasis results.

The publication:

Recent Pat Inflamm Allergy Drug Discov. 2009;3(1):40-8.

NF-kappaB links keratinocytes and lymphocytes in the pathogenesis of psoriasis.

Tsuruta D.

Summary of the abstract

Psoriasis is a common, chronic and relapsing autoimmune skin disease.

The mechanism of this disease is still an enigma, but genetic susceptibility, abnormal function of keratinocytes, or immunological disturbance, especially in T cells, are postulated.

Over the past decades, there have been arguments about “keratinocyte-dependent” pathology as opposed to “immunocyte-dependent” pathology. Now evidence has been presented that while the aberrant NF-kappaB activation in either keratinocytes or lymphocytes could not reproduce psoriasis-like histology, such activation in both reproduced all the “hallmarks” of psoriasis.

Therefore, NF-kappaB may well act as a link between the T cell-mediated and keratinocyte-mediated arguments concerning the pathogenesis of psoriasis.

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