Lactobacillus inhibits NF-kB
The term “probiotic” is used to describe organisms that are used medicinally, including bacteria such as Lactobacillus.
Lactobacillus bacteria are normally found in the small intestine. These are ‘good bacteria’ since they produce vitamin K as well as certain anti-microbial substances which prevent the ‘overgrowth’ of harmful bacteria.
A number of human trials have reported benefits associated with lactobacillus administration for the inflammatory bowel conditions ulcerative colitis and Crohn’s disease.
Lactobacillus has also been shown to benefit asthma patients.
While lactobacillus is generally helpful, the specific means by which it benefits patients with inflammatory bowel disease was uncertain. Researchers have now determined that lactobacillus exerts it anti-colitis effect through inhibition of NF-kB.
The publication:
Int J Colorectal Dis. 2009 Feb;24(2):231-7. Epub 2008 Dec 3.
Lactobacillus suntoryeus inhibits pro-inflammatory cytokine expression and TLR-4-linked NF-kappaB activation in experimental colitis.
Lee JH, Lee B, Lee HS, Bae EA, Lee H, Ahn YT, Lim KS, Huh CS, Kim DH.
Summary of the abstract
OBJECTIVE: Lactic acid bacteria (LAB) can improve disturbances of indigenous microflora as well as inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn’s disease.
We examined the anticolitic effect of Lactobacillus, which is known to inhibit NF-kappaB activation, in a mouse model of colitis.
RESULTS AND DISCUSSION: In the mouse model of colitis we saw colon shortening and also increased markers of inflammation. However, oral administration of Lactobacillus inhibited colon shortening and decreased the level of inflammation markers. Lactobacillus inhibited the NF-kappaB activation, as well as the expression of COX-2.
CONCLUSION: Lactobacillus can improve colitis via the inhibition of NF-kappaB activation.
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