NO synthase inhibitors antagonize CGRP effect

Nitric oxide synthase inhibitors prevent CGRP mediated dilation of blood vessels in a model of migraine.

The publication:

September, 2002

Nitric oxide synthase inhibitors can antagonize neurogenic and calcitonin gene-related peptide induced dilation of dural meningeal vessels.

Summary of the abstract

CGRP antagonists can block both neurogenic and CGRP-induced dural vessel dilation.

Nitric oxide synthase (NOS) inhibitors are effective in the treatment of acute migraine.


One Response to NO synthase inhibitors antagonize CGRP effect
  1. […] NO synthase inhibitors reduce the effects of CGRP – suggesting that CGRP production, release, and activity are dependent on NO. […]