Nitric oxide (NO) appears to play an essential role in migraine.
NO is implicated in migraine:
- Pain transmission
- Chronic pain
- Central sensitization
NO production is increased as a result of NF-kB activation and can be inhibited through the inhibition of NF-kB.
Nitric oxide in migraine.
Summary of the abstract
The potent vasodilatator and messenger molecule nitric oxide (NO) is believed to play a key role in migraine pathogenesis.
NO donors such as glyceryl trinitrate (GTN) can cause headache. Infusion of GTN leads to a migraine attack in migraineurs with a latency of 4 to 6 hours.
This review focuses on the role of nitric oxide and the transcription factor nuclear factor-kappaB (NF-kB) in migraine pathophysiology.
NO is involved in pain transmission, hyperalgesia, chronic pain, inflammation and central sensitization.
NO is implicated in the induction of a migraine attack in migraineurs.