Nitric Oxide, NF-kappaB & migraine

Nitric oxide (NO) appears to play an essential role in migraine.

NO is implicated in migraine:

  • Initiation
  • Pain transmission
  • Hyperalgesia
  • Chronic pain
  • Inflammation
  • Central sensitization

NO production is increased as a result of NF-kB activation and can be inhibited through the inhibition of NF-kB.

The publication:

August, 2007

Nitric oxide in migraine.

Summary of the abstract

The potent vasodilatator and messenger molecule nitric oxide (NO) is believed to play a key role in migraine pathogenesis.

NO donors such as glyceryl trinitrate (GTN) can cause headache. Infusion of GTN leads to a migraine attack in migraineurs with a latency of 4 to 6 hours.

This review focuses on the role of nitric oxide and the transcription factor nuclear factor-kappaB (NF-kB) in migraine pathophysiology.

NO is involved in pain transmission, hyperalgesia, chronic pain, inflammation and central sensitization.

NO is implicated in the induction of a migraine attack in migraineurs.


One Response to Nitric Oxide, NF-kappaB & migraine
  1. […] NO is of central importance in migraine, and NF-kB inhibition has been shown to decrease NO. […]