NF-kB inhibition useful in joint pain generally.
The publication:
April, 2009
Application of NFkappaB inhibitor for arthritis
Summary of the abstract
Recent progress in DNA technologies has provided the strategies to regulate the transcription of disease-related genes.
The concept of regulation the disease related gene expression at the level of transcriptional factor may be more therapeutic compared with other therapies.
Inhibiting NF-kB in an affected joint resulted in marked suppression of joint destruction, with a great reduction in inflammatory cytokines and matrix metalloproteinase production from stimulated synovial cells derived from rheumatoid arthritis patients.
NF-kB inhibition inhibited bone destruction.
Parthenolide is one of the main sesquiterpense lactones responsible for the bioactivities of feverfew and recently reported to inhibit NF-kB activation. Parthenolide has eliminated joint destruction in experimental animal model.
Based upon these findings, NF-kB may be an important therapeutic target for arthritis
