NF-kappaB: Autoimmunity master switch

A review of NF-kappaB and autoimmune disease

The abstract below is a quick overview. It suggests the central importance of NF-kB and then lists a few of the autoimmune conditions related to excess NF-kB activation.

The full text article provides a more thorough review, and is available free online.

The full article includes a number of challenges and potential dangers associated with pharmaceutical inhibition of NF-kB. Note, however, that on this site I’m mainly discussing NF-kB inhibition by means of natural extracts. You’re already doing that – every day (NF-kappaB inhibitors are found in most fruits and vegetables) – it’s just that you might not be doing enough of it, especially since we’re all exposed to more inflammation promoters every day.

Of course natural extracts are not necessarily safe. Some can have side effects at high doses, and some are outright poisonous.

So as an added safety precaution, Banjo uses only those ingredients that have at least a 1,000 year history of safe use and for which no dose, however great, has ever been found unsafe. Then Banjo uses a relatively small amount of each extract, but in combination with a unique “trans-mucosal” delivery system, it’s very effective.

So yes – NF-kB inhibition by synthetic pharmaceuticals will probably cause all sorts of side effects.

But the natural extracts? If it was possible to overdose I’d be long gone. I drink a lot of coffee.

The publication:

December, 2008

The role of nuclear factor-kappaB in the development of autoimmune diseases: a link between genes and environment.

Summary of the abstract (or you can read the free full text online)

Although autoimmune diseases are relatively common, mechanisms that lead to their development remain largely unknown.

Nuclear factor-kappaB (NF-kB), as a key transcription factor involved in the regulation of immune responses and apoptosis, appears to be a good candidate for studies on the pathogenesis of autoimmunity.

This review presents how changes in NF-kB signaling can contribute to self-tolerance failure, initiation of autoimmune inflammatory response as well as its persistent maintenance and therefore to the development of common autoimmune diseases including:

  • rheumatoid arthritis
  • multiple sclerosis
  • diabetes
  • thyroid autoimmune diseases
  • lupus
  • inflammatory bowel diseases
  • psoriasis

Special emphasis is put on the genetic variations in the NF-kB related genes and their possible association with susceptibility to autoimmune diseases, as well as on the therapeutic potential of the NF-kB targeted strategies in the treatment of autoimmunity.

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