NF-kappaB activation in trigeminal nucleus in migraine

Nitroglycerin administration to those with migraine results in excess NF-kB activation in the trigeminal nerve.

In those with migraine, nitroglycerin (NTG) induces severe delayed headache, resembling spontaneous migraine attacks. This has proven to be a good model for migraine.

The publication summarized below sought to explore a possible mechanism by which NTG results in migraine and found that NTG administration resulted in an increase in activated NF-kB in the trigeminal nerve.

The publication:

June, 2005

Activation of the transcription factor NF-kappaB in the nucleus trigeminalis caudalis in an animal model of migraine.

Summary of the abstract

The infusion of nitroglycerin induces an inflammatory state in the tissues covering the brain and spinal cord (meninges) in rats. The inflammation was found to correlate with, and presumably results from, activation of NF-kappaB. The possible role of NF-kappaB in the onser of acute migraine attacks was investigated.

Activation of NF-kappaB in certain areas of the brain was detected in the trigeminal nerve during the nitroglycerin-induced migraine attacks.


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