NF-kB inhibition useful in arthritis generally.

The publication:

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Nihon Rinsho Meneki Gakkai Kaishi. 2009 Apr;32(2):71-6.

Application of NFkappaB inhibitor for arthritis

Tomita T, Kunugiza Y, Nomura K, Morimoto D, Kuroda S, Yoshikawa H.

Department of Orthopaedics, Osaka University Graduate School of Medicine.

Summary of the abstract

Recent progress in DNA technologies has provided the strategies to regulate the transcription of disease-related genes.

The concept of regulation the disease related gene expression at the level of transcriptional factor may be more therapeutic compared with other therapies.

Inhibiting NF-kB in an affected joint resulted in marked suppression of joint destruction, with a great reduction in inflammatory cytokines and matrix metalloproteinase production from stimulated synovial cells derived from rheumatoid arthritis patients.

NF-kB inhibition inhibited bone destruction.

Parthenolide is one of the main sesquiterpense lactones responsible for the bioactivities of feverfew and recently reported to inhibit NF-kB activation. Parthenolide has eliminated joint destruction in experimental animal model.

Based upon these findings, NF-kB may be an important therapeutic target for arthritis

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