With less history of medication use, the inflammatory nature of migraine may be more evident in children
Mediators of inflammation were found to be elevated in children with migraine when compared to children with episodic headache.
Inflammation may be more readily observed in the pediatric migraine population with less previous use of anti-inflammatory medications.
Pediatr Neurol. 2009 Jul;41(1):17-21.
Proinflammatory plasma cytokines in children with migraine.
Boćkowski L, Sobaniec W, Zelazowska-Rutkowska B.
Summary of the anstract
Toward understanding the role of cytokines in migraine, this study focused on selected proinflammatory cytokines.
The study group consisted of 21 children who had migraine with and without aura; the control group was 24 children with episodic tension-type headache.
Plasma interleukin-1 alpha was undetectable in 19 control subjects with tension-type headache, but was detectable in 16 patients with migraine, which suggests that interleukin-1 alpha level might be higher in migraine.
Soluble tumor necrosis factor receptor 1 in the migraine group was significantly higher than in the control group (P < 0.0005).
Migraine patients tended to have increased tumor necrosis factor alpha level, compared with the control group.
The results suggest that proinflammatory cytokines may be involved in the pathogenesis of migraine attacks, although fluctuations in cytokine levels could be different in children than in adults. Such difference could be due to long medical history of migraine in adult patients and frequent intake of analgesic drugs or prophylactic treatment.