Hyperalgesia: Fibromyalgia excess pain sensitivity & cytokines

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Are pro-inflammatory cytokines responsible for the excess pain sensitivity (hyperalgesia) of fibromyalgia?

Science: The pro-inflammatory cytokine (PIC) IL-8 is shown to cause increased pain sensitivity via the sympathetic nervous system.

Conclusion: PIC excess appears to be at least partly responsible for excess pain sensitivity in fibromyalgia.

 

IL-8 may be significant in the pathology of fibromyalgia as a mediator of sympathetic pain.

November, 1991

Interleukin-8 as a mediator of sympathetic pain.

Summary of the Abstract

The hyperalgesic effect of IL-8 was measured, and was shown to result in a dose-dependent hyperalgesia that was not reduced by the COX inhibitor indomethacin.

Therefore a new activity of IL-8 is described which is the ability of IL-8 to generate hyperalgesia through a prostaglandin-independent pathway. IL-8 is therefore shown to cause hyperalgesia that involves the sympathetic nervous system. IL-8 may be the link between tissue injury and sympathetic hyperalgesia.


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