Are pro-inflammatory cytokines responsible for the excess pain sensitivity (hyperalgesia) of fibromyalgia?
Science: The pro-inflammatory cytokine (PIC) IL-8 is shown to cause increased pain sensitivity via the sympathetic nervous system.
Conclusion: PIC excess appears to be at least partly responsible for excess pain sensitivity in fibromyalgia.
IL-8 may be significant in the pathology of fibromyalgia as a mediator of sympathetic pain.
Interleukin-8 as a mediator of sympathetic pain.
Summary of the Abstract
The hyperalgesic effect of IL-8 was measured, and was shown to result in a dose-dependent hyperalgesia that was not reduced by the COX inhibitor indomethacin.
Therefore a new activity of IL-8 is described which is the ability of IL-8 to generate hyperalgesia through a prostaglandin-independent pathway. IL-8 is therefore shown to cause hyperalgesia that involves the sympathetic nervous system. IL-8 may be the link between tissue injury and sympathetic hyperalgesia.