How does Banjo work?

The way in which Banjo acts to relieve symptoms is unknown

Like most drugs, the way in which Banjo acts to achieve relief of symptoms is unknown. Unlike most drugs, Banjo contains a wide variety of unique chemicals. Because Banjo contains plant extracts, and each plant contains hundreds of different chemicals, Banjo may possibly contain thousands of different chemicals.

For that reason, the precise and entire mechanism by which Banjo acts to relieve symptoms may never be known. Approximately 100 years of research was required to understand the mechanism by which aspirin works (in its purified and altered form, aspirin is now a single chemical entity, but it too was originally derived from a plant.)

Our theory on how and why Banjo works

Briefly, many plants contain chemicals that have been found to act as natural anti-inflammatory agents. It may be that nearly every plant exerts at least some anti-inflammatory effect on the human body, but of course some are much more effective in that regard than others.

Those plants most effective as anti-inflammatory agents have generally been shown to act by inhibiting NF-kappaB, a complex protein messenger that seems to act very much as the ‘master switch’ controlling inflammation.

According to our theory, these plants act to prevent the initiation of inflammation. That is, they act at (or before) the very first step in a process that would eventually lead to full-blown inflammation. Certain other anti-inflammatory agents (e.g. aspirin, glucocorticoids) also act on the NF-kappaB ‘master switch’, but seem to only weakly inhibit NF-kappaB activation, with the bulk of their anti-inflammatory activities taking place ‘down stream’ from NF-kappaB, well after inflammatory processes are well-established.

To employ a simple analogy, imagine a match being used to light some dry leaves on the forest floor. Given time, the national guard from several states might not be able to extinguish the ensuing forest fire. But even a child could prevent or extinguish that fire at the ‘match’ stage.

Banjo combines a number of plant extracts that are known to inhibit NF-kappaB activation. Efficacy may be enhanced in that the various agents, while all inhibiting NF-kappaB, achieve that inhibition by various mechanisms. Efficacy may further be enhanced by the administration of these extracts transmucsally, as the use of a lozenge means that the beneficial extract components are largely absorbed through the lining of the mouth, without having to first pass through the harsh environs of the stomach and without being exposed to the ‘first-pass’ effect whereby the liver often degrades even beneficial chemicals before thse reach the systemic circulation.

So, in theory, Banjo is inhibiting NF-kappaB and thereby eliminating inflammation at its source.

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