Anti-cancer effect of 6-shogaol, and active component of ginger, against human non-small cell lung cancer

The publication:

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6-Shogaol, an Active Constituent of Dietary Ginger, Induces Autophagy by Inhibiting the AKT/mTOR Pathway in Human Non-Small Cell Lung Cancer A549 Cells.

Summary of the abstract

This study is the first study to investigate the anticancer effect of 6-shogaol in human non-small cell lung cancer A549 cells. 6-Shogaol inhibited cell proliferation by inducing autophagic cell death, but not, predominantly, apoptosis.

We also found that 6-shogaol inhibited survival.

Taken together, these findings suggest that 6-shogaol may be a promising chemopreventive agent against human non-small cell lung cancer.

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Comments:

Ginger for prevention of lung cancer

6-shogaol is one of the active ingredients found naturally occurring in ginger. It appears to limit reproduction in the cancer cells through a mechanism other than what is usually observed.

The results suggest that ginger may have some effect in preventing non-small cell cancer of the lung.