Feverfew and ginger, delivered sublingually, were effective in preventing migraine progression when administered at the mild pain phase of the acute attack.

Two hours after treatment, 48% of patients were pain free and another 34% had only mild headache pain.

No significant side effects were reported.

A combination of ginger and feverfew, when administered sublingualy at the mild pain phase, was found to be both safe and effective at relieving the pain and associated symptoms of migraine.

The publication:

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Med Sci Monit. 2005 Sep;11(9):PI65-9. Epub 2005 Aug 26.

Gelstat Migraine (sublingually administered feverfew and ginger compound) for acute treatment of migraine when administered during the mild pain phase.

Cady RK, Schreiber CP, Beach ME, Hart CC.

Clinvest, Inc., Springfield and Headache Care Center, Springfield, Missouri, USA.

Summary of the abstract

BACKGROUND: Treatment of migraine headaches is often delayed due to assessing the potential severity of an evolving headache or anticipating unwanted consequences from prescription medication. Studies have demonstrated improved pain-free response when prescription treatments are taken during the mild headache phase of a migraine. This study was designed to evaluate the efficacy of an OTC product, GelStat Migraine, when taken in the early, mild pain phase of migraine.

RESULTS: 29 evaluable subjects completed the study, all treating at mild pain. Two hours after treatment, 48% were pain-free with 34% reporting a headache of only mild severity.

CONCLUSIONS: GelStat Migraine is effective as a first line abortive treatment for migraine when initiated early during the mild headache phase.

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