Feverfew extract for migraine

Feverfew extract found to be safe and effective in the prevention of migraine.

After taking the feverfew extract three times a day, by the third month those migraine patients who experienced an average of 4.76 attacks per month were only experiencing 2.86 attacks per month – a decrease of 1.9 monthly migraine attacks. Whereas those on placebo only experienced a 1.3 migraine per month decrease in monthly attack frequency.

The publication:

Cephalalgia. 2005 Nov;25(11):1031-41.

Efficacy and safety of 6.25 mg t.i.d. feverfew CO2-extract (MIG-99) in migraine prevention–a randomized, double-blind, multicentre, placebo-controlled study.

Diener HC, Pfaffenrath V, Schnitker J, Friede M, Henneicke-von Zepelin HH.

Neurologische Universitätsklinik, Essen, Germany.

Summary of the abstract

The efficacy and tolerability of a CO(2)-extract of feverfew (MIG-99, 6.25 mg t.i.d.) for migraine prevention were investigated.

The primary endpoint was the average number of migraine attacks per 28 days during the treatment months 2 and 3 compared with baseline.

Safety parameters included adverse events, laboratory parameters, vital signs and physical examination.

The migraine frequency decreased from 4.76 by 1.9 attacks per month in the MIG-99 group and by 1.3 attacks in the placebo group.

MIG-99 is effective and shows a favourable benefit-risk ratio.


One Response to Feverfew extract for migraine
  1. […] An extract of feverfew, which is a natural NF-kB inhibitor, has been shown effective in the prevention of migraine. […]