Cytokine therapies for fibromyalgia?

Cytokine therapy for fibromyalgia
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Does cytokine therapy have potential as a treatment for fibromyalgia?

Science: Pro-inflammatory cytokine excess has been documented in fibromyalgia, especially for IL-1, IL-6 and IL-8. These cytokines are known to affect or control prominent symptoms in fibromyalgia, including fatigue, sleep, pain, stress and aching.

Conclusion: Cytokine therapy not only has potential, but might be the ideal treatment for fibromyalgia.

It is hard to describe a possible cause for all of the diverse symptoms of fibromyalgia without making reference to cytokines, especially the pro-inflammatory cytokines IL-1, IL-6 and IL-8. Only pro-inflammatory cytokine excess offers a single, reasonable explanation for fatigue, sleep impairment, cognitive impairment (fibro-fog,) autonomic dysfunction (e.g.postural orthostatic tachycardia syndrome – POTS,) depression, anxiety, and many other frequent but less common symptoms.

To the extent that fibromyalgia symptoms occur as the result of pro-inflammatory cytokine excess (which is substantial,) a therapy which potentially targets cytokine excess is likely to represent an ideal therapy.


Is there a role for cytokine based therapies in fibromyalgia.

Summary of the Abstract

Cytokines act as inter-cellular messengers, and are key regulators of the immune system.

Cytokines are known to control or affect fatigue, fever, sleep, pain, stress and aching.

There is mounting evidence that IL-1, IL-6 and IL-8 are elevated in fibromyalgia syndrome. Therefore therapies intended to normalize cytokine levels in fibromyalgia may be effective as treatments for fibromyalgia.


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