Lemons were first grown in Europe 2,000 years ago - 'only' 1800 years later were they discovered to prevent scurvy - then a common, deadly disease.
Lemons are rich in anti-oxidant and anti-inflammatory chemicals.
Banjo contains a pure water extract of the whole lemon fruit.
Banjo provides fast, effective relief from pain and inflammation because it enables your body’s immune system to function properly. It works just like the fruits and vegetables you eat every day – by naturally inhibiting NF-kB, the inflammation Master Switch.
Banjo works better because it combines the most effective natural extracts and delivers them in a form that ensures maximum bio-availability. You get the full spectrum of phytonutrients your body needs to turn off excess inflammation.
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Endotoxin shock represents an extreme in whole body inflammation. The ability of the citrus flavonoid hesperidin to suppress endotoxin induced shock suggests that it is a powerful anti-inflammatory agent.
The publication:
Biol Pharm Bull. 2004 May;27(5):679-83.
Kawaguchi K, Kikuchi S, Hasunuma R, Maruyama H, Yoshikawa T, Kumazawa Y.
Medicinal Plant Garden, School of Pharmaceutical Sciences, Kitasato University, Kanagawa, Japan.
Administration of a citrus flavonoid hesperidin (HES) to mice before LPS challenge significantly reduced tumor necrosis factor (TNF)-alpha production in a dose-dependent manner.
In addition, HES markedly suppressed plasma levels of TNF-alpha.
Lemon peel is a rich source of nobiletin, found in this study to inhibit NF-kB. Inhibition of NF-kB was associated with a decrease in: NO production, PGE-2, and COX-2, each of which is an important mediator of pain and inflammation in arthritis.
The publication:
J Ethnopharmacol. 2007 Aug 15;113(1):149-55. Epub 2007 May 31.
Choi SY, Hwang JH, Ko HC, Park JG, Kim SJ.
Department of Life Science, Cheju National University, 66 Jejudahakno, Jejusi, Jeju 690-756, Republic of Korea.
Post-treatment with nobiletin, which was purified from the fruit peel of citrus was shown to significantly suppress NF-kB, NO and PGE(2) production, and iNOS and COX-2 protein expression in an animal model of arthritis.
Nobiletin interrupted the DNA-binding activity of activated NF-kappaB.
As reactive oxygen species (ROS) are known to regulate the activation of NF-kB, the effect of nobiletin on LPS-induced ROS generation was tested. Nobiletin significantly inhibited LPS-induced intracellular ROS production.
These results suggest that nobiletin may exert an anti-inflammatory effect through the interruption of NF-kB DNA-binding activity and the suppression of ROS generation.
The publication:
Blood. 1999 Dec 1;94(11):3847-54.
Kawakami A, Nakashima T, Sakai H, Urayama S, Yamasaki S, Hida A, Tsuboi M, Nakamura H, Ida H, Migita K, Kawabe Y, Eguchi K.
The First Department of Internal Medicine, and the Department of Hospital Pharmacy, Nagasaki University School of Medicine, Japan.
When NF-kB is excessively stimulated, cells cannot die normally (this normal cell death is called “apoptosis.”) This study suggests that HTLV-1 results in the activation of NF-kB (so normal cell death does not occur.) This then results in an increase of cytokine production (inflammation) and cell proliferation, which is thought to be one cause of autoimmune disorders such as Sjögren’s syndrome and rheumatoid arthritis.
Aging Alzheimer's Arthritis Asthma Atherosclerosis Back Pain Banjo Cancer Chronic Pain Cluster Headache Crohn's Diabetes Fatigue Fibromyalgia Gout Headache Heart Disease IBD Inflammation Joint Pain Lupus Migraine Multiple Sclerosis Muscular Dystrophy Neck Pain Neuropathic Pain NF-kB Osteoarthritis Pain Parkinson's Psoriasis Rheumatoid Arthritis Sjogren's Stroke TMJ Ulcerative Colitis
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