Dandelion leaves and roots are common ingredients in European herbal medicines. Fresh leaves make an excellent salad.
Dandelion includes anti-oxidants and, as a natural NF-kB inhibitor, reduces pain and inflammation.
Banjo contains a pure water extract of dandelion leaves and roots.
Banjo provides fast, effective relief from pain and inflammation because it enables your body’s immune system to function properly. It works just like the fruits and vegetables you eat every day – by naturally inhibiting NF-kB, the inflammation Master Switch.
Banjo works better because it combines the most effective natural extracts and delivers them in a form that ensures maximum bio-availability. You get the full spectrum of phytonutrients your body needs to turn off excess inflammation.
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Dandelion (Taraxacum officinale) has a long history of use as a natural medicine for the relief of pain and inflammation. On investigating dandelion the researchers whose publication is summarized below demonstrated a diversity of effects attributable to an extract of dandelion, including a reduction in numerous markers of inflammation. The historic use of dandelion is thereby confirmed by modern research.
The publication:
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J Ethnopharmacol. 2008 Jan 4;115(1):82-8. Epub 2007 Sep 15.
Jeon HJ, Kang HJ, Jung HJ, Kang YS, Lim CJ, Kim YM, Park EH.
College of Pharmacy, Sookmyung Women’s University, Cheongpa-dong, Yongsan-ku, Seoul 140-742, Republic of Korea.
Taraxacum officinale (dandelion) has been widely used as a folkloric medicine for the treatment of diverse diseases.
In this study, the dried plant was extracted with 70% ethanol to generate its ethanol extract (TEE).
TEE showed radical scavenging activity, decreased the reactive oxygen species (ROS) level, and had anti-angiogenic activity (significant in the prevention or treatment of cancer.)
In a model of asthma and pneumonia, TEE inhibited production of exudate, and significantly diminished nitric oxide (NO) and leukocyte levels in the exudate. It acted to reduce inflammation. TEE was also analgesic – it decreased pain.
The anti-inflammatory effects of TEE included a reduction in vascular permeability, decreased production of NO, decreased expression of inducible nitric oxide synthase (iNOS) and decreased cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-stimulated macrophages.
Collectively, Taraxacum officinale contains anti-angiogenic, anti-inflammatory and anti-nociceptive (anti-pain) activities through its inhibition of NO production and COX-2 expression and/or its antioxidative activity.
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The publication:
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Bone undergoes continuous remodeling through bone formation and resorption, and maintaining the balance for skeletal rigidity. Bone resorption and loss are generally attributed to osteoclasts.
Differentiation of osteoclasts is regulated by receptor activator of nuclear factor NF-kB ligand (RANKL), a member of tumor necrosis factor family. When the balance is disturbed, pathological bone abnormality ensues.
Through the screening of traditional Korean medicinal plants, the effective molecules for inhibition and stimulation of RANKL-induced osteoclast differentiation in mouse bone marrow macrophages were identified. Among 222 methanol extracts, of medicinal plants, 10 samples exhibited ability to induce osteoclast differentiation.
In contrast, Curcuma longa (turmeric) and Taraxacum platycarpa (dandelion) showed inhibitory effects in RANKL-induced osteoclast differentiation.
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Comments:
Excessive osteoclastogenesis or activation of mature osteoclasts causes bone destruction. Excessive osteoclastogenesis is implicated as contributing to the pathology of rheumatoid arthritis and osteoporosis.
Prevention of excess osteoclast activity can be protective, especially in conditions like rheumatoid arthritis, characterized by excess bone resorption.
The present study suggests that dandelion and turmeric exert a bone protective effect the inhibition of NF-kB.
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